Positive Reinforcing and Anxiolytic Effects of Substance P Injected into the Rat Globus Pallidus

Abstract

Event Abstract Back to Event Positive Reinforcing and Anxiolytic Effects of Substance P Injected into the Rat Globus Pallidus Erika Kertes1*, Kristóf László2, Beáta Berta2 and László Lénárd1, 2 1 Neurophysiology Research Group of the HAS , Hungary 2 Institute of Physiology, Pecs University Medical School, Hungary The tachykinin substance P (SP) facilitates learning. It can induce place preference and also has anxiolytic-like effects. SP has high affinity for neurokinin-1 (NK-1) receptors, but it can also act on NK-2 and NK-3 receptors. By means of immunohistochemistry it has been revealed that the globus pallidus (GP) is rich in SP immunoreactive elements and NK-1 receptors. GP is involved in the organization of memory processes. Learning deficits were found after different lesions of GP. The aim of our experiments was to study the effects of SP injected into the GP on positive reinforcement and anxiety and the possible involvement of NK-1 receptors in these effects. Male Wistar rats were microinjected with 0.4μl of 10 ng SP, 100 ng SP or vehicle. In place preference paradigm significant reinforcing effect was found by 10 ng SP, while 100 ng was ineffective. Microinjections of 10 ng dose of SP in elevated plus maze task had anxiolytic-like profile, it significantly increased the amount of time that rats spent on the open and the end arms of the elevated plus maze. The effects of SP could be blocked by prior treatment with WIN 51,708, a potent nonpeptide NK-1 receptor antagonist. Our results show that in the GP 1) SP has positive reinforcing effect in place preference task, 2) SP has anxiolytic effect in the elevated plus maze model, and 3) these effects are mediated via NK-1 receptors. Supported by ETT 317/2006, RET-008/2005 MEDIPOLIS, NKHT-OTKA K68431 grants and by the HAS. Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Behavioural neuroscience Citation: Kertes E, László K, Berta B and Lénárd L (2009). Positive Reinforcing and Anxiolytic Effects of Substance P Injected into the Rat Globus Pallidus. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.095 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2009; Published Online: 03 Mar 2009. * Correspondence: Erika Kertes, Neurophysiology Research Group of the HAS, Pecs, Hungary, erika.kertes@aok.pte.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Erika Kertes Kristóf László Beáta Berta László Lénárd Google Erika Kertes Kristóf László Beáta Berta László Lénárd Google Scholar Erika Kertes Kristóf László Beáta Berta László Lénárd PubMed Erika Kertes Kristóf László Beáta Berta László Lénárd Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.