Abstract
Tuberculosis (TB) is the leading cause of death in HIV/AIDS. The incidence of active TB is 30 times higher in HIV-infected persons. Treatment of latent TB infection (LTBI) is pivotal to the control of TB. We aim to determine the positive predictive value of an interferon-gamma release assay, QuantiFERON-TB GOLD test (QFT), for incident active TB in HIV-infected persons.
Highlights
Tuberculosis (TB) is the leading cause of death in HIV/ AIDS
Disease occurred in 5.6% (5/90) of those with a positive QuantiFERON-TB GOLD test (QFT) result, 3.2% (1/31) indeterminate results, and 1.4% with a negative QFT result (p=0.03)
Hazard ratio for developing active TB was 3.10 (95%CI:1.03-9.30, p=0.04) for a positive QFT and 1.72 (p=0.60) for an indeterminate QFT result
Summary
Tuberculosis (TB) is the leading cause of death in HIV/ AIDS. The incidence of active TB is 30 times higher in HIV-infected persons. Positive predictive value of Interferon-gamma release assay for incident active tuberculosis in HIV-infected persons Susan Shin-Jung Lee*, Hsi-Hsun Lin, Hung-Chin Tsai, Yen-Yun Ni, Yao-Shen Chen, Chi-Tai Fang From 17th International Symposium on HIV and Emerging Infectious Diseases (ISHEID) Marseille, France. Introduction Tuberculosis (TB) is the leading cause of death in HIV/ AIDS.
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