Abstract
Abstract45S5 bioactive glass (BG) scaffolds show great potential in bone tissue engineering due to their superior osteoinductivity and osteoconductivity. However, such scaffolds generally possess poor mechanical properties. Here, inspired by the reinforcing principle of confined concrete elements in civil engineering, poly caprolactone (PCL)/polyethylene glycol (PEG) film‐wrapped 45S5 BG scaffolds were prepared by gluing highly porous foam–replicated BG scaffolds and electrospun PCL/PEG films together with a PCL layer. The results showed that the compressive strength of the PCL/PEG film‐wrapped scaffolds was greatly improved, compared to that of unwrapped BG scaffolds. Moreover, the PCL/PEG film exhibited hydrophilicity, responsible for improved cell activity with respect to the hydrophobic PCL one. Thus, the present work introduces a convenient approach to improve the mechanical properties of highly porous bioceramic scaffolds, and is relevant for future robust scaffold design.
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