Abstract
Stress-induced phosphoprotein-1 (STIP1), an adaptor protein that coordinates the functions of HSP70 and HSP90 in protein folding, has been implicated in the development of human gynecologic malignancies. This case-control study investigates STIP1 serum levels and tissue expression in relation to endometriosis/adenomyosis in Taiwanese population. Female patients with surgically confirmed endometriosis/adenomyosis were compared with women free of endometriosis/adenomyosis. Serum STIP1 levels were measured using an enzyme-linked immunosorbent assay and surgical tissues were analyzed by immunohistochemistry. Both epithelial and stromal cells in surgical tissues of endometriosis and adenomyosis expressed STIP1 and MMP-9. Notably, MMP-9 expression was significantly decreased when STIP1 expression was knocked-down. In vitro experiments revealed that STIP1 was capable of binding to the MMP-9 promoter and enhanced its transcriptional expression. The preoperative serum STIP1 levels of patients with endometriosis/adenomyosis were significantly higher than those of the controls. In brief, our data suggest an association between STIP1 levels and endometriosis/adenomyosis.
Highlights
Endometriosis has a significant impact on public health, with an estimated prevalence of 5% −10% in women of reproductive age [1]
To the best of our knowledge, this is the first study to show that the upregulation of both Stress-induced phosphoprotein-1 (STIP1) and matrix metalloproteinases (MMPs)-9 is positively related to the pathophysiology of endometriosis/adenomyosis
STIP1 and MMP9 in endometriosis/adenomyosis graph summarizes the decreased protein levels of MMP9 that were caused by STIP1 knockdown in three independent siRNA experiments
Summary
Endometriosis has a significant impact on public health, with an estimated prevalence of 5% −10% in women of reproductive age [1].
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