Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

Minghui Li,Lihua Hu,Lingjuan Zhu,Huihui Bao,Tao Wang,Xiaoshu Cheng,Xiao Huang,Wei Zhou,Aihua Zhan

doi:10.1186/s12933-020-01124-2

Abstract

BackgroundData are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensive patients.MethodsThis study included 4718 hypertensive adults, a subset of the China H-type Hypertension Registry Study. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was determined by measuring brachial-ankle pulse wave velocity (baPWV).ResultsThe overall mean TyG index was 8.84. Multivariate linear regression analyses showed that TyG index was independently and positively associated with baPWV (β, 1.02; 95% confidence interval [CI] 0.83, 1.20). Consistently, Multiple logistic analyses showed a positive association between TyG index risk of elevated baPWV (> 75th percentile) (odds ratio [OR], 2.12; 95% CI 1.80, 2.50). Analyses using restricted cubic spline confirmed that the associations of TyG index with baPWV and elevated baPWV were linear. Subgroup analyses showed that stronger associations between TyG index and baPWV were detected in men (all P for interaction < 0.05).ConclusionTyG index was independently and positively associated with baPWV and elevated baPWV among hypertensive patients, especially in men. The data suggest that TyG index may serve as a simple and effective tool for arterial stiffness risk assessment in daily clinical practice.

Highlights

Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients
TyG index was inversely associated with age, serum homocysteine, High-density lipoprotein cholesterol (HDL-C), and positively associated with body mass index (BMI), waist circumference, diastolic blood pressure (DBP), fasting plasma glucose, total cholesterol, triglycerides, serum uric acid, Low-density lipoprotein cholesterol (LDL-C), and estimated glomerular filtration rate (eGFR)
TyG triglyceride glucose, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, HDL-C high-density lipoprotein cholesterol, LDL-C lowdensity lipoprotein cholesterol eGFR estimated glomerular fltration rate participants in quartile 2, quartile 3, and quartile 4 were 0.59, 0.89, and 1.56, respectively, compared with those in quartile 1 (P for trend < 0.001)

Summary

Introduction

Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensive patients. Arterial stiffness, which is assessed by measuring pulse wave velocity (PWV), is recognized as an important predictor of cardiovascular events and mortality [1,2,3]. The coexistence of abnormal glycolipid metabolism in hypertensive patients greatly enhances the likelihood of these patients developing arterial stiffness. A better understanding of the glycolipid metabolism factors among hypertensive patients may possibly reduce the huge burden of arterial stiffness associated complications

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