Abstract
Background Previous studies have revealed the triglyceride-glucose (TyG) index is closely related to hyperuricemia in the general population. However, this relationship in hypertensive patients has not been reported. The aims of this study are to investigate the relationship of the TyG index and hyperuricemia in adult Chinese hypertension. Methods The China H-type Hypertension Registration (an observational, noninterventional, and real-world study) was conducted from March 01, 2018, to August 31, 2018, in 16 communities in Wuyuan of China. The TyG index was calculated from fasting triglycerides (mg/dL) and fasting glucose (mg/dL)/2. Hyperuricemia was categorized by uric acid concentration ≥420 μmol/L (7 mg/dL). Results Overall average TyG index of 13,060 adults with hypertension was 8.87; age was 63.81 years. The TyG index was positively correlated with serum uric acid by multiple linear regression analyses (β = 38.03; 95% CI: 34.55 to 41.51). Coincidentally, logistic analyses also demonstrated the TyG index had a positive correlation with hyperuricemia (OR = 2.04; 95% CI: 1.87 to 2.24). Strong linear associations of the TyG index with serum uric acid and hyperuricemia were confirmed by restricted cubic spline analysis. Compared with subjects in the lowest quartile (7.13 to 8.44) of the TyG index, subjects in the 2nd–4th quartiles had 1.25 (95% CI: 1.10 to 1.41), 1.63 (95% CI: 1.43 to 1.86), and 2.79 (95% CI: 2.41 to 3.24) times greater incident risk of developing hyperuricemia. The TyG index had significant correlations between male patients and hyperuricemia (OR = 2.01) by subgroup analysis. Conclusion Positive associations were found between the TyG index and serum uric acid and between the TyG index and hyperuricemia in adults with hypertension. This trial was registered at clinicaltrials.gov as ChiCTR1800017274.
Highlights
Previous studies have revealed the triglyceride-glucose (TyG) index is closely related to hyperuricemia in the general population
Hypertension was defined as systolic blood pressure (SBP) ≥140 mmHg or/and diastolic blood pressure (DBP) ≥90 mmHg when blood pressure was measured in a resting and sitting position or taking antihypertensive medications or self-report of a hypertensive diagnosis. e three consecutive measurements were averaged to obtain the final blood pressure values. e exclusion criteria were described as follows: (1) mental or neurological abnormalities that prevent collaboration with the investigation; (2) unable to complete follow-up due to poor adherence or planned to relocate recently; (3) the participants assessed by the study physicians as unsuitable for inclusion or long-term follow-up; and (4) participants with lipid-lowering drugs were excluded, when the drugs’ impact on biochemical indicators was considered [22, 23]
Female, HDL-C, and serum homocysteine tended to decrease with the TyG index, while BMI, waist circumference, SBP, DBP, fasting plasma glucose, total cholesterol, triglyceride, LDL-C, and estimate glomerular filtration rate (eGFR) tended to increase with the TyG index (P values < 0.05)
Summary
Previous studies have revealed the triglyceride-glucose (TyG) index is closely related to hyperuricemia in the general population. This relationship in hypertensive patients has not been reported. E aims of this study are to investigate the relationship of the TyG index and hyperuricemia in adult Chinese hypertension. E TyG index was positively correlated with serum uric acid by multiple linear regression analyses (β 38.03; 95% CI: 34.55 to 41.51). Strong linear associations of the TyG index with serum uric acid and hyperuricemia were confirmed by restricted cubic spline analysis. Positive associations were found between the TyG index and serum uric acid and between the TyG index and hyperuricemia in adults with hypertension. Positive associations were found between the TyG index and serum uric acid and between the TyG index and hyperuricemia in adults with hypertension. is trial was registered at clinicaltrials.gov as ChiCTR1800017274
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