Abstract
Oral mandibular epithelium determines the position and number of tooth organs. Cranial neural crest-derived ectomesenchyme provides inductive signals for (i) tooth shape, and (ii) sequential determination and expression of several different epithelial-derived enamel proteins. Inductive signalling follows a precise sequence, can be expressed in serumless, chemically-defined medium in vitro, and appears to be highly conserved during vertebrate evolution.
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