POSB199 Prevalence of Prurigo Nodularis in the Regional Area of Brittany (France): Estimation by Matching Two Databases

Abstract

The objective of this study was to estimate the PN prevalence in Brittany and to describe treatments. We estimated the prevalence of PN by using 2 health data collection systems: - A registry data from the Brest University Hospital Center; - Medical/administrative data from the French SNDS database which links the hospitalization database (PMSI) with the outpatients claim database. Patients hospitalized between 2009-2018 with a primary or a secondary diagnosis of PN (ICD-10 code L28.1) were identified. The 2 sources were combined to identify patients that would be identified in the 2 databases as having a PN and to estimate the total number of PN patients in Brittany with the capture-recapture method. The prevalence rate was estimated by dividing the number of PN patients (capture-recapture estimate) by resident Brittany population. 63 unique patients with PN were identified: 5 patients in both sources, 21 only in the centre and 37 only in SNDS database. With the capture recapture method, the total number of unique PN cases was 218 (IC95%=[125 – 349]). As there were 3,310,000 inhabitants in Brittany, the prevalence was estimated at 0.07/1000 (IC95%=[0.04;0.11]). Among the 63 patients, 37 (58.7%) were females. Mean age was 70 years. In 2018, 61% of patients received topical corticoids, 49.2% antihistamines, 47.5% antidepressants. In 2009-2018, 93.2% of patients received topical corticoids, 96.6% antihistamines, 64% psychoanaleptics, 52.5% pregabaline. No patients received tacrolimus, pimecrolimus, capsaicin or peripheral opioid receptor antagonists. This study shows a prevalence 0.07/1000 for PN in Brittany. This prevalence appears low, but the French PN definition was very restrictive before the European one.