POS-854 NEGATIVE ALACTIC VALUE IS REVERSED BY HEMOPERFUSION IN SEPTIC PATIENTS

Abstract

Gattinoni et al. have recently introduced a new internal milieu parameter: the “alactic base excess” (ABE). This variable is obtained by applying the following equation: ABE mmol/L = standard base excess (SBE) mmol/L + lactate mmol/L, being standard base excess mmol/L = [bicarbonate mmol/L - 24.8 mmol/L] + 16.2 mmol/L x (pH - 7.4). In a clinical setting, a negative ABE value is directly related to fix acid retention, and is associated with higher mortality in septic patients. Hemoperfusion (HPF) is an extracorporeal technique which involves the passage of blood (or plasma) through an adsorption cartridge, where solutes are removed by direct binding to the sorbent material.