POS-470 CARDIAC BIOMARKERS AS A PREDICTOR OF MORTALITY IN CHRONIC KIDNEY DISEASE PATIENTS IN THE INTENSIVE CARE UNIT

Abstract

The role of B-type natriuretic peptide (BNP) and other cardiac biomarkers (CBs) like Creatine kinase-MB (CK-MB) and troponin I (cTnI) as a prognostic factor in chronic kidney disease (CKD) patients admitted to the intensive care unit (ICU) is not yet established. We aimed to determine whether these CBs are predictive of ICU mortality in critically ill CKD patients. An prospective observational study involving 140 CKD patients carried out in nephrology ICU from January 2015 to July 2015. SOFA score, BNP, CK-MB and cTnI levels recorded at admission were correlated with ICU mortality. The ICU mortality rate was 50.7% (71/140). Time-dependent multivariate regression analysis revealed SOFA (p <0.001) and BNP (p <0.001), at admission were only predictor ICU mortality in CKD patients. The area under the curve (AU-ROC) for BNP was 0.918 with a cut off value of 1585 pg/ml (Sensitivity 87.3, specificity 89.9%) to predict ICU mortality. SOFA score and serum BNP level at admission can significantly predict the ICU mortality in critically ill CKD patient.