POS1533-HPR COMPARISON OF HAND FUNCTIONS AND FUNCTIONAL STATUS IN PATIENTS WITH LIMITED CUTANEOUS SYSTEMIC SCLEROSIS AND DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS

Abstract

BackgroundSystemic Sclerosis (SSc) is an autoimmune connective tissue disorder which is characterised by the fibrotic changes in the skin effecting especially fingers and hands. Regarding skin manifestations, SSc is classified into two different subtypes as limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc).ObjectivesThe aim of the present study was to compare hand functions and functional status in patients with lcSSc and dcSSc.MethodsTwenty-three patients with lcSSc and thirteen patients with dcSSc were included in the study. Modified Hand Mobility in Scleroderma Test (mHAMIS), modified Rodnan skin score (mRSS), grip and pinch strengths were measured to evaluate hand-related physical characteristics. Duruoz Hand Index, Disability of Arm, Shoulder and Hand Questionnaire (DASH), Health Assessment Questionnaire (HAQ), and Scleroderma Health Assessment Questionnaire (SHAQ) were used as the outcomes.ResultsWhile differences were detected in mRSS scores between disease subtypes (p<0.05), hand functions and functional status were comparable between groups (p>0.05).Table 1.Comparison of the groupslcSSc Group Median (IQR 25/75) (n= 23)dcSSc Group Median (IQR 25/75) (n=13)p*mHAMIS (score 0-4)0 (0/1)0 (0/0)0.745mRSS Fingers (score 0-3)2 (1.5/3)3 (2/3)0.100mRSS Hands (score 0-3)1 (0.5/2)2 (2/3)0.020*mRSS Forearms (score 0-3)0 (0/1)2 (1/2)0.013*mRSS Upper Arms (score 0-3)0 (0/0)1 (0/1)0.003*mRSS Total (0-51)8 (5/13)27 (18/29)0.006*Hand Grip Strength (kg)19.7 (11.2/24.6)20.9 (14.4/24.8)0.649Tip to Tip Pinch Strength (kg)3 (2.2/3.9)3.3 (2.4/2.9)0.721Three Jaw Pinch Strength (kg)2.4 (1.7/3.2)2.8 (2/3.5)0.226Lateral Pinch Strength (kg)3.8 (3.4/5.1)4 (3.2/5.3)0.948Duruoz Hand Index (score 0-90)5 (0/17)6 (0/15)0.770DASH (score 30-150)62 (47/84)61 (53/77)0.770HAQ (score 0-3)0.3 (0.1/0.9)0.3 (0.8/0.9)1.000SHAQ-Raynaud’s Phenomenon (score 0-3)0.8 (0/1.4)1.3 (0.3/1.5)0.363SHAQ-Digital Ulcers (score 0-3)0 (0/0.6)0.3 (0/1.7)0.136SHAQ-Gastrointestinal (score 0-3)0 (0/1.5)0.7 (0.1/1.4)0.466SHAQ-Pulmonary (score 0-3)0.5 (0/1.5)1 (0.2/1.5)0.534SHAQ-Patient Global Assessment (score 0-3)1.1 (0.1/2)1.4 (0.8/2.2)0.345p<0.05, *: Mann-Whitney U test, IQR 25/75: Interquartile range between the 25th and 75th percentiles, n: number, mHAMIS: modified Hand Mobility in Scleroderma Test, mRSS: modified Rodnan skin score, DASH: Disability of Arm, Shoulder, and Hand Questionnaire, HAQ: Health Assessment Questionnaire, SHAQ: Scleroderma Health Assessment Questionnaire, lcSSc: limited cutaneous Systemic Sclerosis, dcSSc: diffuse cutaneous Systemic SclerosisConclusionAccording to our results, even though, patients with dcSSc present higher skin thickening compared to patients with lcSSc, hand functions and functional status seem to be similar between SSc subtypes.Disclosure of InterestsNone declared