POS1223 ASSOCIATION BETWEEN NAILFOLD VIDEOCAPILLAROSCOPY FINDINGS AND SKL-6 LEVELS IN PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES–RELATED INTERSTITIAL LUNG DISEASE

Abstract

BackgroundIdiopathic inflammatory myopathies (IIM) are a heterogeneous group of acquired muscle diseases with distinct clinical, pathological and histological features. interstitial lung disease (ILD) is a frequent pulmonary manifestation in IIM (IIM-ILD) and considerably influences morbidity and mortality. Krebs von den Lungen 6 (sKL-6) has been proposed as a potential biomarker reflecting the severity of ILD in connective tissue diseases. Raynaud’s phenomenon is very frequent and the presence of microvascular changes in IIM have been described however, the role of nailfold videocapillaroscopy (NVC) in diagnosis and prognosis in IIM is not clearly established.ObjectivesTo determine if there is any association between NVC findings, sKL-6 levels and pulmonary involvement in patients with inflammatory myopathies.MethodsWe performed a retrospective study of IIM patients followed in a reference center and compared them according to the presence of ILD. Epidemiological, clinical and immunological data, pulmonary function tests (forced vital capacity and diffusing capacity for carbon monoxide), sKL-6 levels and NVC finding were retrieved. NVC findings including loss of capillary density, enlarged and giant capillaries, ramified capillaries, haemorrhages, thrombosis, avascular areas, disorganization of capillary architecture and subpapillary venous plexus presence were recollected, if present. Statistical analysis was performed by T-test and Fisher’s exact test to compare qualitative and/or quantitative variables and multiple logistic regression modelling to identify correlation between pulmonary function tests, NVC findings and sKL-6 levels. Values of p<0.05 were considered statistically significant.Results95 patients were included, 47 patients (49%) with ILD. 34% were male with a median age at inclusion of 55.3±24 years and a median disease duration of 6.8±7 years. Avascular areas and capillary loss showed a significant association with the presence of ILD (OR 2.43, 95% CI 1.3-5.7, p 0.004) and (OR 1.7, 95% CI 1.48-3.1, p 0.04). A negative correlation between capillary loss and enlarged capillaries was also found with FVC% (β=-0.46, p 0.001 and β=-0.57, p <0.0001) and DLCO% (β=-0.32, p 0.04 and β=-0.23, p 0.03), respectively. When we studied the correlation between sKL-6 levels, positive correlations with the presence of ILD (β=0.77, p 0.0004), the presence of hemorrhages (β =0.21, p 0.04) and avascular areas in NVC (β =0.64, p 0.03) and negative correlations with FVC% (β=-0.47, p 0.001) and DLCO% (β=-0.59, p, 0.005) were found. Multiple logistic regression identified as predictors for developing IIM-ILD are summarized in Table 1 and represented in the scatter plot in Figure 1. Male sex, respiratory symptoms, %FVC and %DLCO, sKL-6 levels, anti-Jo1 positivity and the presence of avascular areas and enlarged capillaries in NVC were identified as IIM-ILD predictors (R²=0.974, p =0.006).ConclusionCapillary loss and avascular areas showed a significant association with the presence of ILD, worse FVC and DLCO values and sKL-6 levels. We identified 9 predictors for developing ILD in IIM. NVC assessment and sKL-6 levels can have a predictive role for studying pulmonary function and assessing the prognosis of IIM-ILD.Table 1.Significant logistic regressions for predictors for IIM-ILDPredictorΒ valueP valueMale sex0.1860.036Respiratory symptoms0.400.002%FVC-0.3220.01%DLCO-0.590.001sKL-6 levels0.530.002Anti-Jo 10.280.03Avascular areas0.720.006Enlarged capillaries0.490.04Figure 1: Scatter plotReference[1]Castellví I, Simeón-Aznar CP, Sarmiento M, Fortuna A, Mayos M, Geli C, Diaz-Torné C, Moya P, De Llobet JM, Casademont J. Association between nailfold capillaroscopy findings and pulmonary function tests in patients with systemic sclerosis. J Rheumatol. 2015 Feb;42(2):222-7. doi: 10.3899/jrheum.140276. Epub 2014 Nov 15. PMID: 25399393.Acknowledgements:NIL.Disclosure of InterestsNone Declared.