POS0818 IN PRIMARY SJÖGREN’S SYNDROME CCR9/CXCR5 CO-EXPRESSING EFFECTOR CD4 T CELLS ARE INCREASED AND ARE ENRICHED IN PD-1/ICOS-EXPRESSING T CELLS

Abstract

BackgroundPrimary Sjögren’s syndrome (pSS) is an autoimmune disease characterized by B cell hyperactivity. CXCR5+ follicular helper T cells (Tfh), CXCR5-PD-1hi peripheral helper T cells (Tph) and CCR9+ Tfh-like cells have...