POS0791 DOSE-DEPENDENT RELATIONSHIP BETWEEN HISTORY OF DENTAL CARIES AND INCREASED RISK OF NEWLY-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: A NATIONWIDE POPULATION-BASED COHORT STUDY

Abstract

Background:The relationship between oral bacterial invasion caused by periodontal pathogens and risk of systemic lupus erythematosus (SLE) has been identified. However, there is a lack of knowledge on the relationship between carious lesions and risk of SLE, as well as longitudinal studies on the effect of restorative materials on SLE.Objectives:This study investigated whether patients with history of dental caries are associated with an increased risk of newly-onset systemic lupus erythematosus (SLE).Methods:A total of 541,461 carious patients and 258,918 controls without carious teeth were enrolled between 1997 and 2013 from the National Health Insurance Research Database. Subgroup analyses were conducted based on restorative materials included amalgam, resins or both. Cumulative incidences and hazard ratios (HRs) of developing SLE were derived after adjusting for age, gender, comorbidities and co-medications in a multivariable model.Results:The risk of SLE was significantly higher in carious patients (HR = 1.984, 95% = 1.652-2.382) compared to controls. Dose-dependent relationship between caries and risk of SLE was identified. The risks of SLE were higher among those who had over 11 dental visits (HR = 2.525, 95% C.I = 1.859-3.429), followed by those with 3-10 dental visits (HR = 1.863, 95% C.I= 1.356-2.543), then those with 1-2 visits, and were higher among those who had over 5 carious teeth extractions (HR = 1.877, 95% C.I= 1.186-2.970), followed by those with 1-4 carious teeth extractions (HR = 1.363, 95% CI = 1.167-1.593), then those without extraction. The risk of SLE among different restorative materials, including amalgam or resins, for caries management, were not significantly different.Conclusion:Patients with caries were associated with higher SLE risks. The relationship between caries and risk of SLE was dose-dependent, regardless of used restorative materials.Disclosure of Interests:None declared