POS0447 DIFFICULTIES TO SLEEP EXPLAIN HIGH PATIENT REPORTED OUTCOMES VALUES IN PATIENTS WITH INFLAMMATORY ARTHRITIS WITH NO SWOLLEN JOINTS

Abstract

BackgroundPatient reported outcomes (PROs) are valuable tools to understand how a patient is doing. Patient self-report of pain, fatigue and global health on a 100 mm Visual Analog Scale are routine measures in rheumatology and may be interpreted as measures of disease activity.ObjectivesTo study whether good/poor sleep influences other clinical measures in patients with psoriatic arthritis (PsA) and rheumatoid arthritis (RA).MethodsA total of 13527 (72 % female) patients with rheumatoid arthritis (RA) and 3644 (52 % female) patients with psoriatic arthritis (PsA) were identified in the Finnish national quality register for inflammatory arthritides. Clinical data from the most recent outpatient clinic visit between January 1st 2021 to July 31st 2022 was used in this study. Patients were divided into groups by self-reported difficulty to sleep on a MDHAQ question “over the last week, were you able to get a good night’s sleep” with response options “without any difficulty” and “with some difficulty” as good sleep and “with much difficulty” and “unable to do” as poor sleep. Median values with interquartile ranges of other clinical measures were compared between the groups. Descriptive statistics and regression models were used for comparison with p=0.05 as a threshold for statistical significance.ResultsThe mean (SD) age was 62 (14) for patients with RA and 55 (14) for patients with PsA. A total of 16 % of RA patients and 22 % of PsA patients had poor sleep. The values for DAS28, SJC 66, TJC 68, CRP and ESR were low and similar in patients with poor sleep and good sleep. The VAS-values for pain, fatigue and PGA for RA patients with good sleep were 18 (6, 40), 17 (4, 42) and 23 (9, 46) and 54 (29, 74), 64 (43, 80) and 56 (39, 72) (p<0.001 for all comparisons) for patients with poor sleep. In patients with PsA, the corresponding numbers were 20 (6, 41), 17 (4, 40) and 19 (6, 38) and 59 (36, 74), 66 (44, 81) and 56 (38, 73) (p<0.001 for all comparisons). The results were similar for PROs in patients with PsA (n=942) and RA (n=2861) with an SJC66 of 0. (Figure 1.)ConclusionThe assessment of sleep is crucial for patients presenting severe symptoms without markers of disease activity.Figure 1.Median VAS-values for pain, fatigue and PGA in patients with PsA and RA with poor sleep and good sleep. All patients had no swollen joints.REFERENCES:NIL.Acknowledgements:NIL.Disclosure of InterestsNone Declared.