POS0401 SERUM ANTIBODIES TO TYPE I COLLAGEN IN PERIPHERAL ARTHROPATHY ASSOCIATED WITH INFLAMMATORY BOWEL DISEASE

Abstract

BackgroundImmunological disorders play an important role in the pathogenesis of inflammatory bowel disease (IBD). Type I collagen (COL1) is the main component of the intercellular matrix of connective tissue. It can be assumed that the immune disorders leading to the production of autoantibodies to collagen play a role in the pathogenesis of arthropathy associated with IBD.Objectivesto study the level of IgM and IgG to type I collagen (COL1) in peripheral arthropathy associated with IBD.MethodsWe prospectively included 91 patients with IBD [61 ulcerative colitis (UC), 30 Crohn’s disease (CD)] and 30 healthy controls. 82 patients with IBD were in disease attack and 9 in the remission Mean age in IBD was 36 [28; 47] years and in control group – 35 [25; 48]. Joint involvement (arthralgia, arthritis) was observed in 33 patients (36%). Affected joints were the knees 17 (51%), shoulders 6 (18%), feet 6 (18%), hands 5 (15%), elbows 4 (12%), ankles 3 (9%), wrists 2 (6%). Levels of serum IgM and IgG to COL1 were assessed by enzyme immunoassay.ResultsLevels of IgM to COL1 in active IBD (0,18 [0,10; 0,2] mkg/ml; р<0,01) and in remission (0,15 [0,11; 0,20] mkg/ml; р<0,05) were increased compared with healthy (0,09 [0,07; 0,12] mkg/ml). There were no differences between stage of disease (remission and exacerbation), IBD severity (p>0,05). IgM antibodies to COL1 in patients with peripheral arthropathy (0,174 [0,12; 0,28] mkg/ml) were significantly higher than in patients without joint involvement (0,12 [0,08; 0,19] mkg/ml; р<0,01).The levels of IgG to COL1 in active IBD (14,4 [10,22; 33,34] mkg/ml; р<0,05) and in remission (28,82 [16,36; 78,9] mkg/ml; р<0,005) were higher than in the control group 11,36 [6,93; 19,83] mkg/ml. We didn’t find any differences in IgG levels depending on the severity of disease. IgG levels to COL1 in patients with peripheral arthropathy (16,18 [9,46; 26,21] mkg/ml) were higher, than without them (12,78 [8,81; 28,31] mkg/ml), also not significant.ConclusionIn active IBD the level of serum antibodies of class IgM and IgG to COL1 increased compared with healthy. The maximum increase was found in the patients with peripheral arthropathy, which can be explained by the high content of this collagen in the structural components of the joints and by joint inflammation in patients with IBD.Disclosure of InterestsNone declared.