Abstract
Nephrotoxicity of anticancer drug is increased in presence of pre-existing CKD & presence of concomitant comorbidities. Proposed mechanisms of platin toxicity include apoptosis, mitochondrial dysfunction, autophagy and DNA damage. Commonest side effect of platins is nephrotoxicity. Carboplatin is more chemically stable and causes less nephrotoxicity than cisplatin, but low plasma protein binding and considerable renal elimination may produce undue toxicity in patients with decreased renal function.
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