POS0096 SJÖGREN’S DISEASE AND SYSTEMIC LUPUS ERYTHEMATOSUS DDX6-CXCR5 RISK INTERVALS REVEAL COMMON SNPS WITH FUNCTIONAL SIGNIFICANCE IN IMMUNE AND SALIVARY GLAND CELLS

Mandi M Wiley ,M L Joachims,J A James,T Witte,A M Stolarczyk,B M Warner,R H Scofield,A Nagel,B Tsao,A Rasmussen,C Lessard,S J Bowman,P M Gaffney,X Mariette,B Khatri,M Rischmueller ,W F Ng ,L Radfar ,L Ronnblom ,K Sivils ,K L Tessneer ,Marie Wahren‐Herlenius ,R Omdal ,G Nordmark ,R Jonsson

doi:10.1136/annrheumdis-2022-eular.2503

POS0096 SJÖGREN’S DISEASE AND SYSTEMIC LUPUS ERYTHEMATOSUS DDX6-CXCR5 RISK INTERVALS REVEAL COMMON SNPS WITH FUNCTIONAL SIGNIFICANCE IN IMMUNE AND SALIVARY GLAND CELLS

Mandi M Wiley , M L Joachims + Show 23 more

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https://doi.org/10.1136/annrheumdis-2022-eular.2503

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Journal: Annals of the Rheumatic Diseases	Publication Date: May 23, 2022
Citations: 1

Affiliation: Oklahoma Medical Research Foundation, Hannover Medical School, National Institute of Dental and Craniofacial Research, Medical University of South Carolina, University Hospitals Birmingham NHS Foundation Trust, Assistance Publique – Hôpitaux de Paris, Inserm, University of Paris-Saclay, Bicêtre Hospital, Institut Polytechnique de Paris, University of Adelaide, Newcastle University, University of Oklahoma Health Sciences Center, Uppsala University, Stavanger University Hospital, University of Bergen

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Abstract

BackgroundSjögren’s Disease (SjD) and Systemic Lupus Erythematosus (SLE) are autoimmune diseases with several shared characteristics and similar genome-wide significant associations with the DDX6-CXCR5 locus. DDX6 suppresses interferon-stimulated gene expression and...

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