POS-798 THE HISTOPATHOLOGY OF PATIENTS UNDERGOING RENAL BIOPSY IN ROYAL DARWIN HOSPITAL FROM THE YEAR 2007 TO 2020

Abstract

Since the early 1950s, renal biopsy has become the gold standard for the diagnosis of pathologic renal diseases. Renal biopsy is a very common procedure that gives diagnosis and guidance in management of kidney diseases. With the use in conjunction with serologic, urinary and genetic testing, the histopathology of renal biopsy carries critical information in terms of optimum management (1). The Northern Territory is one of Australia’s most culturally diverse places with more than 100 nationalities (2). Around 46% of the population is culturally diverse, with 26% being indigenous Territorians and 20% born overseas (3). Royal Darwin Hospital (RDH) is the main tertiary hospital that has performed more than 600 biopsies since its establishment in the Northern Territory. However, the histopathology pattern in patients undergoing renal biopsy in Royal Darwin Hospital is still under discussed. The distribution and incidence of kidney diseases vary globally over time and may be highly affected by local standard practice patterns. Thus, it is crucial to have a population-based effort to inform trends in disease spectrum and biopsy histopathology pattern. These data could be informative in making health policies and resource allocation, facilitate funding in research and refine pre-test probabilities in clinical practice We aimed to analyse demographic characteristics, clinical indication and histopathologic diagnoses in population-based cohort. Retrospective cohort study was done for all patients with native biopsy at Royal Darwin Hospital from June 2007 to June 2020. Biopsies were classified by International Society of Nephrology criteria with clinical indications and histopathology results obtained from electronic health records. We used descriptive statistic to summarise age, sex, type of biopsy and histopathological pattern. Annual biopsy rates, age and sex adjusted, were calculated as per the Northern Territory population and demographic data listed on the Australian Bureau of Statistics. Categorical values were expressed as absolute frequencies and percentages; age was categorized into age groups of 10-19, 20-29, 30-39, 40-49, 50-59, 60-69,70-79 and 80-89. Data were further divided into male indigenous, female indigenous, male non-indigenous and female non-indigenous. Clinical indications of each native renal biopsy were stratified and analyzed. Statistical analyses were performed using Business Intelligence. Multivariate analyses was done. A p-value of less than 0.05 was considered statistically significant. We assumed a Poisson distribution to estimate measures of central tendency and variance of rates. Incidence was defined as the number of new cases of biopsy-proven GN in the calendar year, expressed as per hundred thousand people per year. The population would be divided according to age group, sex and aboriginal status. Age group of 40-49 years old has the highest biopsy rate (21.4%). IgA nephropathy is the most prevalent histopathological group in native biopsy. I. The analysis of each histopathology diagnosis for indigenous and non-indigenous females and males would be finalized. IgA nephropathy is the most common histopathology diagnosis among native renal biopsy in The Northern Territory.