POS-702 IMPACT OF DONOR-RECIPIENT GENDER ON GRAFT SURVIVAL

Abstract

A number of donor and recipient factors have been identified that increase the risk of both early and late adverse outcomes after kidney transplantation. Most literature has emphasized the importance of immunologic mismatches; however, earlier studies have also demonstrated that nonimmunologic factors may influence graft and patient outcome.The aim of this study was to analyze whether sex mismatch between donor and recipient influence survival results of kidney transplant grafts. We performed a cohort-retrospective study using data on kidney transplantation ,done between January 1995 to December 2014 in our department. All patients achieved a minimum follow-up of 5-years.The patients were subdivided into four groups according to recipient and donor gender. Graft survival was calculated by the Kaplan–Meier method and compared using the log rank test. The study cohort included 133 kidney transplant recipients with a mean age of 31,58±9.8 years. Of these, 63.2% of kidneys were from female donors and 71.4% of recipients were male.The proportion of female donor–male recipient;male donor–male recipient;male donor–female recipient and female donor–female recipient were 54.1%,24.1%,12.8%,9% respectively. Female donor to male recipient had the inferior long-term graft survival (70.8% have graft estimated Glomerular Filtration RateGFR <60 ml/min at 5 years) compared to the other groups male donor–male recipient (62.5%);male donor–female recipient (52.9%)and female donor–female recipient (33.3%)(P < 0.01). Previous studies have shown inferior outcome when female kidneys are transplanted into male patients. A finding that might be explained by nephron-underdosing theory. The results presented confirm this hypothesis and suggest that the sex matching between donors and recipients should be considered as a criterion for choice of donor and recipient pairs.