POS-531 LIPID PROFILE AND CARDIOVASCULAR RISK IN CHRONIC HEMODIALYSIS PATIENTS

Abstract

Dyslipidemia is a major risk factor for the occurrence of atherosclerosis and cardiovascular diseases. Associated with chronic renal failure, the cardiovascular risk becomes very high. Hence the interest of screening lipid disorders in patients with end-stage renal failure at the hemodialysis stage. We conducted an observational study of the prevalence of lipid disorders in hemodialysis patients in our unit with assessment of their cardiovascular risk in correlation with the Framingham score. The survey involved 40 patients with an average age of 48,775 years [25-78]. The sex ratio was 0.81. Initial nephropathy was dominated by vascular nephropathy in 15 hemodialysis patients, followed by glomerular nephropathy in 13 patients, and tubule-interstitial nephropathy in the remaining 12. The prevalence of dyslipidemia was 52.5%. Lipid disorders were, in decreasing order of frequency; an isolated hypertriglyceridemia at 52.38%; mixed dyslipidemia associating hypercholesterolemia and hypertriglyceridemia at 47.61%. However, 47.5% did not have lipid disorders. Cardiovascular risk assessment according to the Framingham score revealed a high risk in 12.5% of patients who were predominantly male smokers with physical inactivity, a moderate risk in 20% and a low risk in the majority with a frequency of 67.5%. This survey found a high prevalence of dyslipidemia with an important cardiovascular risk. This should lead to develop a better strategy to prevent cardiovascular diseases. Dyslipidemia should be detected and treated in patients with predisposing factors because they are at high cardiovascular risk. The lipid profile should not be interpreted according to laboratory standard but according to target values.