Abstract
Tubulointerstitial inflammation and fibrosis are strong predictors of progression in all kidney diseases regardless of etiology. Receptor tyrosine kinases such as platelet-derived growth factor receptor (PDGFR) and discoidin domain receptors (DDRs) contribute to renal inflammation and fibrosis. ANG-3070 is an inhibitor of multiple tyrosine kinases receptors including PDGFR and DDR. This study evaluated whether ANG-3070 can slow the progression of fibrosis in the unilateral ureteral obstruction (UUO) mouse model of renal fibrosis.
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