Abstract

Diabetic nephropathy (DN) has become one of the main causes of end-stage renal disease. It is characterized by microalbuminuria to massive proteinuria with renal dysfunction. Therefore, how to reduce or prevent the occurrence of proteinuria has a very important reality significance. N6-methyladenosine (N6-methyladenosine, m6A) methylation is considered to be the most abundant and common modification in eukaryotic RNA. The role of m6A modification includes regulation of mRNA stability, shearing, transport, positioning, Translation and RNA-protein interaction, etc.

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