Abstract
Type-2 Diabetes mellitus (T2DM) is the leading cause of CKD and ESRD across the world. Albuminuria is widely accepted as the earliest marker of nephropathy and is used for early diagnosis of diabetic kidney disease (DKD). Classically, the development of overt proteinuria mark the initiation of GFR decline. However, in the last few years growing evidence has shown that a significant proportion of T2DM patients has decreased GFR without albuminuria.
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