Abstract
Emerging studies reported that tubulointerstitial injury plays a critical role in the progression of diabetic kidney disease(DKD).Tubulointerstitial injury mediated by imbalace of mitochondrial quality control (MQC) is essential for DKD pathogenesis. When mitochindria under stress,degrading of denatured proteins or misfolded proteins is blocked,transcriptional activation of mitochondrial molecular chaperones and protease gene populations encoded by nuclear DNA was initiated to maintain mitochondrial protein homeostasis——a process called mitochndrial unfolded protein response(UPRmt) which is crucial for MQC.Activating transcription factor 5(ATF5) function as the nuclear transcription factor of UPRmt in mammal,whether it involves in the tubule damage of DKD through UPRmt pathway remains unclear.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.