Abstract
Hypertension complicates up to 10% of UK pregnancies and is associated with three to five-fold increased risk of pre-eclampsia and adverse perinatal outcome with associated long-term increased risk of cardiovascular disease. The selection of antihypertensive agents in pregnancy is restricted due to concerns over potential adverse effects on the fetus. Amlodipine is used as a first line agent to manage hypertension in many settings outside pregnancy but its safety in human pregnancy is uncertain.Our objective was perform a systematic review of amlodipine use in pregnancy and its association with adverse maternal and perinatal outcome.
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