Abstract
Malaria is a vector-borne disease caused by Plasmodium group and it’s transmitted to humans via bites from the infected female Anopheles mosquitoes. The disease burden of malaria is staggering particularly in Sub-Saharan Africa followed by South-East Asia. Initial manifestations of malaria include fever and flu-like symptoms. Severe malaria is characterized by the presence of hyperparasitemia, metabolic acidosis, severe anemia, hypoglycemia and organs involvement (cerebral and renal). Traditionally, we had hypothesized that the sequestered parasitized erythrocytes in the micro-circulation causing tissue hypoxia underlying severe malaria.
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