Abstract
Complete and partial remission (CR/PR) for focal and segmental glomerulosclerosis (FSGS) have been used clinically as surrogate markers for improved long-term outcome. However, the impact of having a relapse after achieving remission on renal survival is unknown. We evaluated biopsy-proven FSGS patients with nephrotic range proteinuria who had a subsequent CR or PR with a 12-month minimum follow-up. We studied whether time in remission state (proteinuria <3.5 g/d) is associated with improved long-term outcome and if any clinical/laboratory factors were associated with the observed subsequent relapse and remission pattern.
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