POS-118 CYTOMEGALOVIRUS INFECTION AFTER KIDNEY TRANSPLANTATION:clinical feature and risk factors

Abstract

Cytomegalovirus (CMV) reactivation or infection is the major infectious complications after renal transplantation. If not treated, it causes a high rate of morbidity and mortality. We studied demographic features, risk factors, and outcomes associated with CMV infection in renal transplant recipients. We retrospectively analyzed 86 patients who received a renal allograft from 2010 to 2019. CMV infection was defined by CMV DNA detection with a polymerase chain reaction. CMV infection was observed in (7/86) 8.1% of the recipients during the follow-up. 57.1% were men. The mean age was 46.4+- 9.4 years. All our patients were seropositive (D+/R+) prior to transplantation. The average time to diagnosis of CMV infection was 9 months with a median at 4.5 months and extremes between 2 and 30 months. All our patients were symptomatic: elevated creatinine levels was the most common symptom (100%), followed by diarrhea and leucopenia (48.6%). Compared with non infected patients, those with CMV infection presented poorer renal function within the first year post transplantation and more acute rejection episode. CMV infection was associated with age of the transplant recipients (P = 0.002), use of mycophenolate mofetil (P = 0.039), anuria prior to kidney transplantation (p=0,016) and number of mismatches at HLA-B (p=0,038). Given the frequency and the poor outcomes of CMV infection among kidney transplant-recipients, an early detection seems to be necessary in particular that it responds promptly to antiviral treatment