POS-075 ACCURACY OF URINE BIOMARKERS TISSUE INHIBITOR OF METALLOPROTEINASES-2 AND INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-7 ([TIMP-2]∙[IGFBP-7]) IN PREDICTING ACUTE KIDNEY INJURY AMONG ADULT HOSPITALIZED COVID-19 PATIENTS

B Pangan,M.C.T Pornillos,D Guevara,J Poblete,J.J Besa,E.M Masamayor,M.C Lozada,B.R Panganiban,A.J Davin,J.A Balane,M.I Duavit

doi:10.1016/j.ekir.2022.01.084

POS-075 ACCURACY OF URINE BIOMARKERS TISSUE INHIBITOR OF METALLOPROTEINASES-2 AND INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-7 ([TIMP-2]∙[IGFBP-7]) IN PREDICTING ACUTE KIDNEY INJURY AMONG ADULT HOSPITALIZED COVID-19 PATIENTS

B Pangan, M.C.T Pornillos + Show 9 more

Open Access

https://doi.org/10.1016/j.ekir.2022.01.084

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Journal: Kidney International Reports	Publication Date: Feb 1, 2022
License type: NO-CC CODE

Affiliation: Philippine General Hospital

#Insulin-like Growth Factor Binding Protein-7 #Kidney Disease Improving Global Outcomes + Show 8 more

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Abstract

A considerable percentage of patients hospitalized for COVID-19 presented with acute kidney injury (AKI), the most common pathology of which was acute tubular injury. Of the biomarkers studied, the cell cycle arrest biomarkers tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor binding protein-7 (IGFBP-7) present in the urine after being released by tubular cells in response to injury were found to be superior in predicting AKI Kidney Disease Improving Global Outcomes (KDIGO) stages 2 and 3 acute kidney injury.

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