Abstract
Enterohemorrhagic Escherichia coli (EHEC) associated hemolytic uremic syndrome (eHUS) represents one of the major causes of acute kidney injury in children. It is proposed that the progression of the disease is directly linked to the interaction and activation of complement by one of EHEC's main virulence factors, Shiga toxin 2a (Stx2a). Recently it has been discovered that the biological properties and binding abilities of Stx2a, including its interaction with complement proteins, are determined by the structure of its A subunit.
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