Abstract

Ascites is defined as the pathological accumulation of excess free fluid within the peritoneal cavity. This review article summarizes the pathogenesis and management of ascites due to cirrhosis and portal hypertension. The development of ascites signifies the transition from a compensated to a decompensated phase of cirrhosis. Management of ascites in patients who fail conventional therapy is a topic of ongoing research, as the only definitive treatment in such cases is liver transplantation. The latest recommendations on sodium restriction, the use and discontinuation of diuretics, novel treatment modalities including the placement of a transjugular intrahepatic portosystemic shunt (TIPS) and automated low-flow ascites pump (Alfapump®), and discontinuation of beta receptor antagonists in refractory ascites are discussed in a concise and practical way for the general practitioner involved in the care of patients with end-stage liver disease.

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