Abstract
Diversion of portal venous blood into the systemic circulation is associated with a high incidence of peptic ulcer in man. 1 Gastric secretory levels in patients with portacaval shunts are not above normal, but are probably elevated from preoperative values. 2 In the dog, portacaval shunting definitely enhances the rate of acid secretion by the stomach. 3 This has been shown to be due to a circulating substance, probably histamine. 4 The purpose of the present study was to determine, in the dog, changes in gastric, duodenal, pancreatic, and esophageal blood flows following creation of portacaval shunts. The radioisotope ( 42 K or 86 Rb) distribution method was used to measure tissue blood flows. Materials and Methods End-to-side portacaval anastomoses were constructed in nine healthy mongrel dogs. The control group consisted of 13 normal animals that had undergone no operation. All dogs were fed a standard diet of commercial dry cereal
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