Abstract
Treatment of grating stimulation has been used in amblyopia for decades, but high dropout rate and inconvenience for daily practice occur in previous studies. We developed a home-based portable system with rotating grating stimulation on a tablet. Thirty anisometropic amblyopic children were randomly allocated into the control or Grating group. They drew contour of the picture under patch of a better eye for 6 months. Best-corrected visual acuity (BCVA), grating acuity (GA), and contrast sensitivity (CS) were assessed at the baseline, 1st, 2nd, 3rd, and 6th months of training. All participants completed the 6-month training. Patched eyes of both groups exhibited no difference. Trained eyes of the control group had significantly slight improvement in BCVA and GA. In particular, the Grating group exhibited significantly higher BCVA, GA, and CS compared with those of the control group at the 3rd and 6th months of training. Moreover, percentage of the Grating group with great improvement (BCVA ≥ 0.3 or CS ≥ 0.3) was significantly larger than those of the control group at the 3rd or 6th months of training. The portable grating stimulation system demonstrates its trainability by no dropout and effectiveness by significant improvements in all assessments through a well experimental design.Trial Registration: ClinicalTrials.gov NCT04213066, registered 30/12/2019, https://clinicaltrials.gov/ct2/show/NCT04213066.
Highlights
Treatment of grating stimulation has been used in amblyopia for decades, but high dropout rate and inconvenience for daily practice occur in previous studies
Best-corrected visual acuity (BCVA) of the control group exhibited no significant difference throughout training
BCVA of the Grating group exhibited significantly better at the 3rd and 6th months compared with its baseline
Summary
Treatment of grating stimulation has been used in amblyopia for decades, but high dropout rate and inconvenience for daily practice occur in previous studies. Thirty anisometropic amblyopic children were randomly allocated into the control or Grating group They drew contour of the picture under patch of a better eye for 6 months. Thereafter, a Cambridge (CAM) vision stimulator with part-time occlusion has been proposed to force using amblyopic eye under grating stimuli of various spatial frequencies for 10–60 min a day lasting for 2–6 months[9,10,11,12]. Most of the video games for amblyopia are a bsence[24] or only presence of a single-frequency grating stimulation[21] These studies present a considerable dropout rate during the training[21,24]. A systematic evaluation in different aspects of visual functions will be important for effectiveness of CAM stimulator in amblyopia
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
