Abstract
To the Editor.— Kaufman et al 1 reported that they calculated low-density lipoprotein cholesterol concentration by subtracting the high-density lipoprotein cholesterol concentration and one fifth of the triglyceride concentration from the total cholesterol concentration. 2 As I have stated elsewhere, 3 this equation was developed with conventional units and must be adapted before application with Systeme International (SI) units: the triglyceride concentration must be divided by 2.18 instead of 5. Also, the Friedewald formula is valid only if the triglyceride level is below 4.52 mmol/L. 4,5 Kaufman et al 1 excluded specimens only if they were lipemic, but those with triglyceride concentrations between 4.52 and 6.77 mmol/L are not necessarily grossly lipemic, so the absence of lipemia does not mean that the equation can be validly applied in this range.
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