Portable All-in-One Electroanalytical Device for Point of Care

Abstract

Recent technological advancements such as an expansion of available biomarkers and an incremental burden of chronic and infectious diseases made point of care (POC) devices in strong demand. It has a potential to surpass conventional lab-based devices in terms of time, cost, accessibility, and even accuracy. This potential strongly depends on an availability of affordable and miniaturized electronic POC devices that can provide a fast and sensitive response. This paper presents an all-in-one electroanalytical device (AED) which is a cost-effective, field-ready, and miniaturized electronic POC device integrated with the most commonly used electroanalytical techniques such as amperometric, voltammetric, potentiometric, conductometric, and impedimetric techniques. The proposed AED can analyze multiple electrochemical sensors simultaneously while having a very small size of 48 mm <inline-formula> <tex-math notation="LaTeX">$\times37$ </tex-math></inline-formula> mm, including eight disposable screen-printed electrochemical sensor (SPES) connectors. The device supports wired communication using a universal serial bus (USB) and wireless communication with Bluetooth Low Energy (BLE). Furthermore, user-friendly customized Graphical User Interface (GUI) has been developed to control the device and send obtained data to the user. The system is evaluated through electrical tests to confirm the device accuracy. Subsequently, electrochemical experiments were conducted to evaluate device&#x2019;s performance in the field. These experiments indicated that the developed device operates as an electrochemical sensing device for POC applications. The proposed portable electroanalytical device can perform the most of electroanalytical methods in a single device which has very small form factor and capability to interpret multiple sensors at a time with user friendly interface.