Portable Acquisition of Auditory ERPs: A Pilot Study of Premature Infants

Abstract

BackgroundPrior work suggests that event-related potential (ERP) studies in infancy may help predict developmental outcome. MethodsAs part of a longitudinal study of early child development, we used the auditory oddball stimulus paradigm with a portable electroencephalography system to obtain ERP data from two-month-old infants (32 term, six preterm) in Sri Lanka. The mismatch negativity was calculated between 200 and 350 milliseconds after stimulus presentation. ResultsWe found a significant correlation between birth weight and mismatch negativity (P = 0.046), and our time-frequency analysis indicated power differences between standard and oddball tones at approximately 5 and 18 Hz. There was no significant difference between mismatch negativity in children undergoing ERP studies in a hospital setting (30) versus in the child's home (eight). ConclusionsAlthough our modest sample size precludes drawing definitive conclusions, these preliminary results show that it is possible to acquire ERP datasets using currently available portable technology in a hospital or home setting, even in a developing nation such as Sri Lanka. Follow-up of this cohort will include developmental assessments, which will add to the growing literature relating early electrophysiology to developmental outcome.