Abstract
To search for possible cancer chemopreventive agents from natural sources, we performed primary screening of metabolites of Alternaria porri by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. The ethyl acetate extract of A. porri showed the inhibitory effect on EBV-EA activation. Three porritoxins (1–3) were obtained as inhibitory active compounds for EBV-EA from ethyl acetate extract. 6-(3′,3′-Dimethylallyloxy)-4-methoxy-5-methylphthalide (2) showed the strongest activity among them. Inhibitory effect of porritoxin (1) and (2) was superior to that of β-carotene, a well-known anti-tumor promoter. Furthermore, the structure–activity correlation of porritoxins and their related compounds were discussed.
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