PORPHYSOMES-A PARADIGM SHIFT IN TARGETED DRUG DELIVERY

Revathy B Menon,Lakshmi V S,Sreeja C Nair,Aiswarya M U,Keerthana Raju

doi:10.22159/ijap.2018v10i2.23493

Revathy B Menon, Lakshmi V S + Show 3 more

Open Access

https://doi.org/10.22159/ijap.2018v10i2.23493

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Abstract

A novel drug delivery system is the one that ensures optimum dose at the right time, at the right location. Porphysomes are among those drug delivery systems. Porphysomes are a means of vesicular drug delivery systems. They are liposome-like structures composed completely of porphyrin lipid. The porphysomes encapsulates the active medicament in vesicular structure. They are having an aqueous core which can be loaded with the medicament. They have the capacity to destroy the disease tissues. They absorb the heat in the near infrared region and release this heat to destroy the diseased tissues. Porphysomes are having immense applications in the field of positron-electron therapy (PET), photoacoustic imaging, photothermal therapy etc. This review article discusses regarding the Porphysome-the drug delivery system, its advantages and disadvantages, composition, method of preparation, applications and various aspects related to the porphysomal drug delivery.

Highlights

In the past few years, a great focus has been laid on the development of different novel drug delivery systems (NDDS) [1,2,3,4,5]
The porphysomes are a means of vesicular drug delivery systems
These vesicular systems enhance the existence of drugs in systemic circulation and thereby decreases toxicity. It possesses multimodal biophotonic properties. They are used in photoacoustic imaging, positron emission tomography (PET), magnetic resonance imaging (MRI) and image tracked drug delivery

Summary

Introduction

In the past few years, a great focus has been laid on the development of different novel drug delivery systems (NDDS) [1,2,3,4,5]. The porphysomes are a means of vesicular drug delivery systems. They are liposome-like structures composed completely of porphyrin lipid. Porphysomes are having an aqueous core that can be loaded with therapeutic drugs [12]. All these challenges were overcome by the introduction of novel colloidal drug delivery system called porphysomes.

Results

Conclusion