Porphyromonas Gingivalis K6 Serotype IgG Titers Predict Prenatal Depression Scores

Abhishek Wadhawan,Mark A Reynolds,Robert K Ernst,Neil Constantine,Robert Schifferle,Ahmed Abouhamda,Hina Makkar,Aline Dagdag,Cedric Harville,Samia Dutra,Marueen W Groer,Teodor T Postolache

doi:10.1016/j.biopsych.2020.02.827

Porphyromonas Gingivalis K6 Serotype IgG Titers Predict Prenatal Depression Scores

Abhishek Wadhawan, Mark A Reynolds + Show 10 more

https://doi.org/10.1016/j.biopsych.2020.02.827

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Journal: Biological psychiatry	Publication Date: May 1, 2020
Citations: 1

Affiliation: St. Elizabeths Hospital, University of Maryland, Baltimore, University at Buffalo, State University of New York, University of South Florida, Mental Illness Research, Education and Clinical Centers

#Periodontal Disease #Perinatal Depression + Show 8 more

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Abstract

Both perinatal depression (PN) and periodontal disease (PD) are prevalent and associated with negative maternal and fetal outcomes. Porphyromonas gingivalis (Pg), the leading microbe implicated in PD, induces immune changes and translocates to distant sites, including the placenta. We have previously reported positive associations between PgK6 serotype IgG and cardinal symptoms of depression. Now, we explore links between Pg serotypes and perinatal depression scores.

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