Porphyrins in Tumor Phototherapy

Abstract

I: Physics and Chemistry of Porphyrins and Related Compounds.- Excited State Properties of Haematoporphyrin.- Fluorescence Properties of HpD and its Components.- The Structure of the Active Component of Hematoporphyrin Derivative.- Photophysical and Photosensitizing Properties of Photofrin II.- On the Purification of Hematoporphyrin IX and its Acetylated Derivatives.- Photosensitizing Properties of Porphyrin in Model Cell Systems.- Photosensitizing Properties of Free and Bound Uroporphyrin I.- Chemical and Biological Studies on Haematoporphyrin Derivative: An Unexpected Photosensitization in Brain.- A Chromatographic Study of Hematoporphyrin Derivatives.- Protection by Carotenoids from Singlet Oxygen Photoproduced by Porphyrins.- Effect of He-Ne Laser on Human Erythrocytes Incubated with Hematoporphyrin Derivative and Bonellin: Comparative Study.- Survey of Potential PRT Dyes and their Spectroscopic Properties.- II: Interactions of Porphyrins with Model Systems and Cells.- Fluorescence of Porphyrins in Cells.- Hematoporphyrin Derivative: Fluorometric Studies in Solution and Cells.- Time-Resolved Laser Fluorescence and Photobleaching of Single Cells after Photosensitization with Hematoporphyrin Derivative (HpD).- Effects of Hpd and Laser on Transformed and Corresponding Normal Cultured Cells: Differential Cytotoxicity as an in Vitro Model for Tumor Photochemotherapy.- Interaction of Free and Liposome-Bound Porphyrins with Normal and Malignant Cells: Biochemical and Photosensitization Studies in Vitro and in Vivo.- Photodynamic Inactivation of L929 Cells after Treatment with Hematoporphyrin Derivative.- Bacterial and Yeast Cells as Models for Studying Hematoporphyrin Photosensitization.- Cholesterol Impregnation into Erythroleukemia Cell Membrane Induces Resistance to Hematoporphyrin Photodynamic Effect.- Photodynamic Effect of the He-Ne Laser with HpD on the Ultrastructure of Rhabdomyosarcoma Cell.- III: Studies on Experimental and Spontaneous Animal Tumors.- Hematoporphyrin Derivative Phototherapy in Experimental Oncology.- Photoradiation Therapy (PRT) of Lewis Lung Carcinoma in B6D2 Mice, Dosimetry Considerations.- Study of Irradiation Parameters in HpD Phototherapy of MS-2 Tumor Model.- Experimental ENU Induced Brain Tumors with HpD and Dye Laser Light.- Studies with Hematoporphyrin Derivative in Transplantable Urothelial Tumors.- Time Dependence of 3 H Hematoporphyrin Derivative Distribution in the Digestive Tract of the Rat.- Nd YAG Destruction of Tumor Sensitized or Non Sensitized by HpD.- HpD Phototherapy on Spontaneous Tumors in Dog and Cat.- IV: Light Dosimetry and Instrumentation for Tumor Diagnosis and Phototherapy.- Thermal and Optical Dosimetry for Photoradiation Therapy of Malignant Tumors.- Photophysics and Dosimetry of Photoradiation Therapy.- An Optimised Laser System for the Evaluation of HpD Therapy.- A Multi-Led Source for Photoradiation Therapy.- Side Radiation Optical Fibers for Medical Applications.- Fluorescence of Hematoporphyrin-Derivative for Detection and Characterization of Tumors.- In Vivo Fluorescence Excitation Spectra of Hematoporphyrin-Derivative (HpD).- In Vivo Observation of Porphyrin and of the Light Action.- Monitoring of Hematoporphyrin Injected in Humans and Clinical Prospects of its Use in Gynecologic Oncology.- V: Clinical Applications of HpD Phototherapy.- Hematoporphyrin Derivative Photoradiation Therapy, in Theory and in Practice.- Evaluation of Photoradiation Therapy (PRT) in 20 Cases of Cancers.- Hematoporphyrin Phototherapy of Malignant Tumors.- Hematoporphyrin-Derivative and Phototherapy in Extensive Basal-Cell Carcinoma of the Dorsal Skin.- Hematoporphyrin Derivative Photoradiation Therapy of Endobronchial Lung Cancer.- Photoradiation Therapy in Early Stage Cancer Cases of the Lung, Esophagus and Stomach.- Experimental and Clinical Studies on HpD-Photoradiation Therapy for Upper Gastrointestinal Cancer.- Endoscopic HpD-Laser Photoradiation Therapy (PRT) of Cancer.- Dye-Laser Photoradiation-Therapy of Bladder Cancer after Photosensitization with Hematoporphyrin Derivative (HpD)-Basis for an Integral Irradiation.- Photoradiation Therapy with Hematoporphyrin Derivative and an Argon Dye Laser of Bladder Carcinoma.- Preclinical Examination of Ocular Photoradiation Therapy.- Photoradiation for Choroidal Malignant Melanoma.