Abstract
Porphyrin is the most common photosensitizer for photodynamic therapy (PDT) where its interaction with light and oxygen generates cytotoxic singlet oxygen species. We recently discovered a unique porphyrin nanostructure, called porphysome, which converts the singlet oxygen generating PDT mechanism of porphyrin molecules to a completely thermal mechanism for efficient photothermal therapy (PTT). This nanostructure-driven PDT to PTT conversion is based on the extremely high porphyrin packing density (>80,000/particle) in porphysome that induces super light absorption and super-quenching of photodynamic activity. Here we explored a reverse process by using receptor-mediated endocytosis to facilitate the disruption of the nanostructure inside cells, thus rapidly switching the PTT mechanism of porphysome to the PDT effect of porphyrin molecules. Therefore, we are closing the loop between PDT and PTT by tailoring the nanostructure-dependent activation mechanism.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
