Abstract
Summary Some cases of porphyria cutanea tarda have been associated with the use of the organochlorine insecticide lindane and the organophosphorous insecticide diazinon. In the case of diazinon, an impurity is the active agent. This impurity has been identified as an isomer of diazinon and is designated isodiazinon. In rats treated with diazinon and isodiazinon, increased faecal excretion of porphyrins was seen oniy in animals treated with both compounds. In these animals the enzyme ferrochelatase was significantly inhibited. It is suggested that porphyria eutanea tarda only arises on exposure to these agents in persons with a pre-existing deficiency of uroporphyrinogen decarboxylase.
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