Abstract
s / Placenta 34 (2013) A1–A99 A15 Conclusion: Detailed placental measures collected by simple imaging methods illuminate placental functional efficiency, a key factor in gestational life that is likely important in fetal programming. PCA demonstrates the complex interactions between lateral expansion of the chorionic plate surface, branching growth of chorionic surface vessels, and arborisation of the fetal stem villi to create the placental surface exchange area that makes up disk thickness. Measurement of any single dimension can lead to misleading conclusions because in different combinations, specific measures may have opposite effects on beta. http://dx.doi.org/10.1016/j.placenta.2013.06.044 P1.8. POROUS MEDIA FLOW MODELS FOR MATERNAL PLACENTAL CIRCULATION Christopher Ball , David Grynspan , Andree Gruslin 3,4 Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada; Department of Pathology and Laboratory Medicine, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada; Department of Obstetrics and Gynecology, The Ottawa Hospital, Ottawa, Ontario, Canada; Department of Cellular Molecular Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada Introduction: It is reasonable to believe that the presence of abnormal flow patterns in the chorionic vessels is an earlier and more sensitive predictor of IUGR than altered end diastolic flow in the umbilical artery. It furthermore appears that the prediction of IUGR becomes increasingly sensitive as predictive flowmeasurements are taken increasingly distal (to the fetus) in the umbilical cord. This, we hypothesize, results from remodelling of the villous circulatory beddthe most proximate correlate of the factors that lead to IUGR. The effect of lacunar blood flow, the intimately connected maternal side of placental flow, cannot be ignored. Aim:Our aim is tomodel the fluidmechanics of the normalmaternal lacunar blood flows in order to assess its influence on flow within the measurable parts of the fetal arterial tree. In view of the placental structure, we aim to apply a model of flow through porous media to the maternal flow bed. Methods: Preliminary inquiry has lead us to suspect that this flowproblem is analogous to the problem of laminar flow through a porous medium (such as in models of fuel cells, ground water, etc.). Here we will illustrate application of this canonical flow model to that of the maternal placenta. Discussion: The problem of modelling EDFR provides an example where interdisciplinary collaboration between medicine and engineering hopefully will permit rapid progress through novel application to one field of established constructs from another. http://dx.doi.org/10.1016/j.placenta.2013.06.045 P1.9. ECHOCARDIOGRAPHIC ANALYSES OF PREGNANCIES IN THE PLACENTAL GROWTH FACTOR KNOCKOUT MOUSE Kristiina Aasa , Bruno Zavan , Philip Wong , Yat Tse , Stephen Pang , B. Anne Croy 1 Queen's University, Kingston, ON, Canada; UNIFAL-MG, Alfenas, Minas
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