Abstract
Bacterial infections at the wound site still remain a huge problem for current medicine, as they may lead to development of chronic wounds. In order to prevent such infections, there is a need to use wound dressings that possess ability to inhibit bacterial colonization. In this study, three new curdlan-based biomaterials modified with copper ions were fabricated via simple and inexpensive procedure, and their structural, physicochemical, and biological properties in vitro were evaluated. Received biomaterials possessed porous structure, had ability to absorb high amount of simulated wound fluid, and importantly, they exhibited satisfactory antibacterial properties. Nevertheless, taking into account all evaluated properties of new curdlan-based biomaterials, it seems that Cur_Cu_8% is the most promising biomaterial for management of wounds accompanied with bacterial infections. This biomaterial exhibited the best ability to reduce Escherichia coli and Staphylococcus aureus growth and moreover, it absorbed the highest amount of simulated wound fluid as well as enabled optimal water vapor transmission. Furthermore, Cur_Cu_8% biomaterial possessed the best values of selective indexes, which determine its potential safety in vitro. Thus, Cur_Cu_8% hydrogel may be considered as a promising candidate for management of infected wounds as well as it may constitute a good platform for further modifications.
Highlights
Microbial growth is considered as a crucial factor, which affects the rate of wound healing [1,2,3,4].Development of bacterial infections at the wound site leads to prolonged inflammation stage, which does not allow for proper wound healing and may lead to sepsis or even to patient dead [1,4,5,6,7].Prevention of bacterial colonization as well as management of bacterial infections at the wound site require the use of appropriate dressings
Performed SEM analysis revealed that all biomaterials possessed rough and porous structure Porous structure is considered as an important property of biomaterial because it significantly increases (Figure 1)
It was demonstrated that the higher specific surface has better absorbent properties [33]
Summary
Prevention of bacterial colonization as well as management of bacterial infections at the wound site require the use of appropriate dressings. Such biomaterials must primarily be non-toxic, non-allergenic, and non-adherent. They should be semi-permeable for water and oxygen, should absorb wound exudate, and maintain moist environment at the wound site. Most important, they must prevent bacterial colonization [1,3,6,8,9,10].
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