Abstract
Considerable research efforts have been directed in recent years towards the development of porous carriers as controlled drug delivery matrices because of possessing several features such as stable uniform porous structure, high surface area, tunable pore size and well-defined surface properties. Owing to wide range of useful properties porous carriers have been used in pharmaceuticals for many purposes including development of floating drug delivery systems, sustained drug delivery systems. Various types of pores like open, closed, transport and blind pores in the porous solid allow them to adsorb drugs and release them in a more reproducible and predictable manner. Pharmaceutically exploited porous adsorbents includes, silica (mesoporous), ethylene vinyl acetate (macroporous), polypropylene foam powder (microporous), titanium dioxide (nanoporous). When porous polymeric drug delivery system is placed in contact with appropriate dissolution medium, release of drug to medium must be preceded by the drug dissolution in the water filled pores or from surface and by diffusion through the water filled channels. The porous carriers are used to improve the oral bioavailability of poorly water soluble drugs, to increase the dissolution of relatively insoluble powders and conversion of crystalline state to amorphous state.
Highlights
Considerable research efforts have been directed in recent years towards the development of porous carriers as controlled drug delivery matrices because of possessing several features such as stable uniform porous structure, high surface area, tunable pore size and well-defined surface properties
Greater attention has been focused on the development of porous materials as controlled drug delivery matrices because of possessing several alternatives features such as stable uniform porous structure, high surface area, tunable pore sizes with narrow distribution and well defined surface properties[7,8]
When a porous hydrophobic polymeric drug delivery system is placed in contact with the appropriate dissolution medium, release of drug to medium must be preceded by the drug dissolution in the water filled pores or from surface and by diffusion through the water filled channels[18]
Summary
When porous polymeric drug delivery system is placed in contact with appropriate dissolution medium, release of drug to medium must be preceded by the drug dissolution in the water filled pores or from surface and by diffusion through the water filled channels. Greater attention has been focused on the development of porous materials as controlled drug delivery matrices because of possessing several alternatives features such as stable uniform porous structure, high surface area, tunable pore sizes with narrow distribution and well defined surface properties[7,8]. When a porous hydrophobic polymeric drug delivery system is placed in contact with the appropriate dissolution medium, release of drug to medium must be preceded by the drug dissolution in the water filled pores or from surface and by diffusion through the water filled channels[18]. Supermicroporosity (size-1.4-2.0 nm) promotes co-operative pore filling wherein monolayer formation occurs and the pore diameter is effectively reduced enhancing the adsorption potential of the pore
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