Abstract
In the present study, we successfully synthesized a porous three-dimensional Prussian blue-cellulose aerogel (PB-CA) composite and used it as a decorporation agent for the selective removal of ingested cesium ions (Cs+) from the gastrointestinal (GI) tract. The safety of the PB-CA composite was evaluated through an in vitro cytotoxicity study using macrophage-like THP-1 cells and Caco-2 intestinal epithelial cells. The results revealed that the PB-CA composite was not cytotoxic. An adsorption study to examine the efficiency of the decorporation agent was conducted using a simulated intestinal fluid (SIF). The adsorption isotherm was fitted to the Langmuir model with a maximum Cs+ adsorption capacity of 13.70 mg/g in SIF that followed pseudo-second-order kinetics. The PB-CA composite showed excellent stability in SIF with a maximum Cs+ removal efficiency of 99.43%. The promising safety toxicology profile, remarkable Cs+ adsorption efficacy, and excellent stability of the composite demonstrated its great potential for use as an orally administered drug for the decorporation of Cs+ from the GI tract.
Highlights
13.70 mg/g in simulated intestinal fluid (SIF) that followed pseudo-second-order kinetics
An edible Prussian blue-cellulose aerogel (PB-cellulose aerogel (CA)) composite was fabricated as a decorporation agent for the removal of Cs+ from the GI tract
The Scanning electron microscopy (SEM) images revealed a 3D porous morphology in which the cubic Prussian blue (PB) NPs were uniformly distributed on the cellulose matrix
Summary
13.70 mg/g in SIF that followed pseudo-second-order kinetics. The PB-CA composite showed excellent stability in SIF with a maximum Cs+ removal efficiency of 99.43%. Radioactive cesium (137Cs) is the most harmful naturally occurring radionuclide, with a long half-life (30.17 years) and high water solubility and mobility, which readily enters the animal and human food chains through the consumption of contaminated water, plants, meat, fish, and milk[11,12]. Decorporation agents enhance the elimination or excretion of absorbed radioactive contaminants, are associated with the absorption of 137Cs from the GI tract into the systemic circulation, and improve elimination after absorption; they are of great use for the minimization of the absorbed radiation dose when people are exposed to these radionuclides[4,16]. Owing to the similar biological nature of Cs and Na/K, decorporation agents should have a high selectivity for Cs to avoid electrolytic imbalances caused by the elimination of Na and K from the GI tract[1,17,18,19]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
