Porophyllum Genus Compounds and Pharmacological Activities: A Review

María José Vázquez-Atanacio,Mirandeli Bautista-Ávila,Manasés González-Cortazar,Carolina Guadalupe Sosa-Gutiérrez,Claudia Velázquez-González,Deyanira Ojeda-Ramírez,Araceli Castañeda-Ovando

doi:10.3390/scipharm89010007

María José Vázquez-Atanacio, Mirandeli Bautista-Ávila + Show 5 more

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https://doi.org/10.3390/scipharm89010007

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Abstract

The genus Porophyllum (family Asteraceae) is native to the western hemisphere, growing in tropical and subtropical North and South America. Mexico is an important center of diversification of the genus. Plants belong of genus Porophyllum have been used in Mexican traditional medicine to treat kidney and intestinal diseases, parasitic, bacterial, and fungal infections and anti-inflammatory and anti-nociceptive activities. In this sense, several trials have been made on its chemical and in vitro and in vivo pharmacological activities. These studies were carried on the extracts and isolated compounds and support most of their reported uses in folk medicine as antifungal, antileishmanial, anti-inflammatory, anti-nociceptive and burn repair activities, and as a potential source of new class of insecticides. Bio guided phytochemical studies showed the isolation of thiophenes, terpenes and phenolics compounds, which could be responsible for the pharmacological activities. However, more pre-clinical assays that highlight the mechanisms of action of the compounds involved in pharmacological function are lacking. This review discusses the current knowledge of their chemistry, in vitro and in vivo pharmacological activities carried out on the plants belonging to the Porophyllum genus.

Highlights

A growing world-wide interest in the use of phytopharmaceuticals as complementary or alternative medicine, either to prevent or to ameliorate many diseases, has been noted in recent years
Chemical Constituents Isolated from Plants of the Genus Porophyllum
It should be noted that monoterpenes, such as sabinene, β-pinene, α-phellandrene, terpinen-4-ol, and limonene, and other compounds, such as bithiophenes (Figure 1), are the most abundant compounds identified in this genus (Table 1)

Summary

Introduction

A growing world-wide interest in the use of phytopharmaceuticals as complementary or alternative medicine, either to prevent or to ameliorate many diseases, has been noted in recent years. Plants of the genus Porophyllum (family Asteraceae) are native to the western hemisphere, growing in tropical and subtropical areas from North and South America [2,3,4,5,6,7] It consists of 25 species [8], 17 of which are found in Mexico, with Guerrero, Morelos, Puebla, and Hidalgo, the main states of large-scale production [2]. These are annual or perennial plants that possess developed green leaves with aromatic glands and a strong flavour.

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