Abstract
Introduction: Unless promptly treated, disturbances of bone and mineral metabolism during the course of chronic kidney disease can lead to serious complications. These abnormalities as well as other factors related to the uremic state affect the skeleton and result in disruption of homeostasis in the bone and mineral turnover. It is manifested by abnormal concentration of phosphorus and calcium in serum and tissues and changes in the concentration of PTH. The spectrum of skeletal abnormalities seen in renal osteodystrophy includes: osteitis fibrosa, osteomalacia, adynamic bone disease (ABD), osteopenia or osteoporosis and combinations of these abnormalities termed mixed renal osteodystrophy. Aim of the study: The aim of our study was to assess biochemical parameters of mineral and bone metabolism in hemodialysis patients. Patients and Methods: The research involved 30 patients (retrospective type of study), mean age 62.43; fifteen men (50%) and fifteen women (50%). Patients were divided into groups in respect to the length of dialysis treatment (group I - up to 5 years, group II - 5-10 years and group III - over 10 years). Conclusion: Serum phosphorus, calcium, alkaline phosphatase and PTH values were increased with duration of dialysis. The most reliable marker for clinical monitoring of bone disease in dialysis patients is PTH, which correlates well with the values of alkaline phosphatase (p=0,006) and calcium (p=0,021).
Highlights
Unless promptly treated, disturbances of bone and mineral metabolism during the course of chronic kidney disease can lead to serious complications
Serum phosphorus, calcium, alkaline phosphatase and PTH values were increased with duration of dialysis
MILJKOVIĆ 25 bone turnover-high turnover), osteomalacia, adynamic bone disease (ABD) in which we find very low turnover with reduced formation of bone tissue as a consequence of long-term hypocalcaemia resulting from the use of calcium-based phosphorus binders over a long period of time and high concentration of calcium in dialysis fluid, 4 osteopenia and osteoporosis, and a combination of all of these abnormalities, which is called mixed renal osteodystrophy
Summary
Disturbances of bone and mineral metabolism during the course of chronic kidney disease can lead to serious complications These abnormalities as well as other factors related to the uremic state affect the skeleton and result in disruption of homeostasis in the bone and mineral turnover. It is manifested by abnormal concentration of phosphorus and calcium in serum and tissues and changes in the concentration of PTH. Osteitis fibrosis and ABD have nearly the same frequency of occurrence and in patients on peritoneal dialysis, adynamic bone disease is dominant. 5
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
