Abstract

Automated patch-clamp setups are applied to investigate dose response relationships and target kinetics in the development of new pharmaceutical agents. Currently, automated systems are limited to investigations of suspended single cells. We pursue the development of assays for detecting the membrane properties in adherent networks because the majority of cells in humans grow adherently. In a first step, we developed PoreGenic®, a novel patch-clamp system for cells growing on a sensor chip with micro-structured needle electrodes arranged in an 8×8 multi-electrode array with a pitch of 100 μm.

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